ea0070aep418 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020
Pashkovska Nataliia
, Koval Galina
, Pashkovska Olga
, Abramova Nataliia
, Marchuk Yulia
, Pankiv Ivan
, Piddubna Antonina
Introduction: Diabetes mellitus is known as a factor of cognitive impairment. The risk of dementia in patients with type 2 diabetes mellitus (T2DM) increases almost twice. The results of epidemiological, visualization and autopsy studies showed the presence of both cerebrovascular and neurodegenerative mechanisms of brain lesions. Cell death of key substrates – neurons and endothelial cells lays in the basis of the formation of cerebral disorders. Granzyme B (GrB) is a s...